Cold Plasma Diabetic Foot Ulcer Clinical Trial Published

https://www.woundsinternational.com/journals/issue/667/article-details/efficacy-non-thermal-gas-plasma-treatment-diabetic-foot-ulcers-stalled-subclinical-biofilm-related-wound-infection

Congratulations to Dr Cornelia Wiegand for her published clinical trial paper, “The efficacy of non-thermal gas plasma in the treatment of diabetic foot ulcers stalled by subclinical, biofilm-related wound infection”. This clinical trial paper features the use of our SteriPlas Cold Plasma medical device for the treatment of chronic DFUs infected with biofilm.

 

The parameters of this study were set much higher than a normal study, with there being a much higher standard of care given (3x per week) vs a typical outpatient setting of 1x weekly.

 

We wanted to show that even when chronic diabetic foot ulcers are subjected to more frequent outpatient visits with biopsies and swabs included (something not often collected during standard outpatient visits), SteriPlas Cold Plasma still prevails as the successful treatment method due to its physical mode of action and ability to kill all types of bacteria protected within biofilm.

 


Presenting at The Advanced Wound Care Summit Europe

 

We’re looking forward to the Advanced Wound Care Summit Europe conference. On the 13th December, our Managing Director, Mary McGovern, will be presenting “Cold Plasma Medicine – Clinical Trials and Regulatory Challenges” where she will explain the importance of clinical trials to test the safety and efficacy of a medical device and the challenges that one can expect.

Since we were the first company worldwide to introduce cold plasma treatment on wounds in clinical trials, it comes to no surprise that we have good experience in this field. Adtec Healthcare boasts a wide collection of clinical trials and studies of our SteriPlas cold plasma medical device to authenticate the efficacy, safety and no side effects claims that we state.  We have proven clinical efficacy of managing infections in diabetic foot ulcers and surgical site infections where other treatments have failed.

 

Evident to our success, this is why Adtec Healthcare’s clinical trials and studies are often referenced by other cold plasma manufacturers who do not have their own clinical studies. With patient safety in mind, clinical trials proving the efficacy must be completed by each manufacturer for the technology used in their device.


New Wound Management of Driveline Infections with Cold Atmospheric Plasma

 

We’re ecstatic to see Dr Jamila Kremer’s publication, “New Wound Management of Driveline Infections with Cold Atmospheric Plasma” is now live for public viewing. The paper can be viewed here: https://doi.org/10.3390/jcdd9110405.

 

The use of our Adtec cold plasma medical device has greatly benefitted her LVAD infection patients treated at the University Heidelberg Hospital since 2019. The results stipulate a stronger infection management advantage over conventional therapy alone for LVAD infections. This is coupled with the benefit of our cold plasma being safe, painless, contact-free and free from side effects.

Driveline infections are the most prevalent infections and reported in up to 60% of LVAD patient cases. Infection of the LVAD system is the fourth most common cause of death within one year after implantation. Dr Kremer’s publication documents Adtec cold plasma treated patients showed a 100% survival rate.

 

For more information about the benefits of our Cold Plasma medical device, contact us at info@adtecplasma.com


The ISHLT discusses the Cold Plasma Project

We’re ecstatic to see our Adtec SteriPlas continue to raise awareness in the LVAD community. A great interview between the ISHLT and Mr Thomas Schlöglhofer from the Medical University of Vienna discussing the benefits of our cold atmospheric plasma medical device for the treatment of LVAD Infections and their broad study being conducted.

Thomas has been an avid user of our medical device for some time now collecting remarkable results with his LVAD patients, documenting the strong benefits of our medical device including the significant reduction of infection rates coupled with full healing, reduction of readmittance and the stabilisation of LVAD systems all with the added benefit of no side effects.

We look forward to the completion of this study and the publishing of the data which will be discussed at the ISHLT 2023 conference next year. We will also be exhibiting at this conference and excited to meet more people from the LVAD community.

 

https://youtu.be/6-L0sgXLx9o


Antimicrobial (antibiotic) Resistance – the drugs won’t work !

Antimicrobial resistance (AMR) poses a significant global threat of far-reaching proportions. It is estimated that drug resistant infections contribute to nearly 5 million deaths every year and predicted to increase to over 10 million deaths every year.  WHO has declared that AMR is one of the top 10 global public health threats facing humanity.

(The worldwide total deaths from COVID is now just over 6 million and we all know how frightening it was before the vaccine was developed)

 

AMR occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death. As a result, the medicines become ineffective and infections persist in the body, increasing the risk of spread to others. Microorganisms that develop antimicrobial resistance are sometimes referred to as “superbugs”. Without effective antimicrobials, the success of modern medicine in treating infections, including during major surgery and cancer chemotherapy, would be at increased risk. Chronic infections if left untreated could result in tissue damage, amputation, longer stays in hospitals, surgical interventions, or increased possibility of mortality. Patients who are infected with drug-resistant infections are more likely to develop complications and are up to three times more likely to die from the infection. Non-healing wounds in particular, are characterised by complex and mixed bacterial populations, often involving antibiotic-resistant bacteria as well as phenotypically tolerant bacteria in biofilm form. The biofilm factor is clearly of considerable clinical importance: it protects bacteria from antimicrobial agents leading to persistent and difficult to treat chronic infections, and it exacerbates the spread of antibiotic resistance. Surgical Site Infections are also linked to anti-microbial resistance.

 

SteriPlas cold plasma technology kills bacteria by a physical mode of action and bacteria are therefore unlikely to develop primary or secondary resistance, which we have documented from our clinical studies. SteriPlas cold plasma also kills antibiotic resistant bacteria (e.g. MRSA) and kills bacteria encased in biofilm which are typically up to 1000 times more resistant to antibiotics. SteriPlas has proven clinical efficacy in treating wound infections,  diabetic foot infections and surgical site infections in all clinical studies, all with the bonus of no side effects reported. 

 

SteriPlas cold plasma can be used to treat topical infections reserving antibiotics for severe systemic infections.

 

References

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext

https://www.worldometers.info/coronavirus/

https://www.who.int/health-topics/antimicrobial-resistance

https://healthfirsteurope.eu/wp-content/uploads/2020/11/A3A4-48pp-Booklet-Spreads-1.pdf

Bowler, P., Murphy, C. & Wolcott, R. Biofilm exacerbates antibiotic resistance: Is this a current oversight in antimicrobial stewardship?. Antimicrob Resist Infect Control 9, 162 (2020).


Our patented 6 electrode Cold Plasma Torch

The Adtec SteriPlas features a patented 6 electrode cold plasma torch. It’s proven efficacy for the destruction of all forms of bacteria including multi-resistant bugs makes it an alternative to antibiotic therapy for the treatment of wounds, surgical site infections and medical dermatology skin conditions. This is due to the unique physical mode of action delivered with our cold plasma as opposed to the chemical mode of action demonstrated with antibiotics. Broader studies have shown that antimicrobial resistance is unlikely to be generated with cold plasma treatment because of this.

 

A huge collection of our peer reviewed publications documents the clinical efficacy and safety of our medical device across a broad range of conditions including diabetic foot ulcers, left ventricular assist device (LVAD) infections, deep sternal wound infections, actinic keratoses and acne.

 

To learn more about our medical device or to obtain one in your clinic practice, please contact us at info@adtecplasma.com

 


Adtec Healthcare's Conference and Exhibition attendance dates for 2022

As we look forward to a promising year ahead, please find the dates of our conference and exhibition participation for 2022:

Society for Cardiothoracic Surgery (SCTS) Annual Meeting – 8-10 May 2022

Malvern Diabetic Foot Conference – 11-13 May 2022

European Wound Management Association (EWMA) – 23-25 May 2022

Diabetic Foot Study Group (DFSG) – 16-18 September 2022

 

We hope to see you at either of these conferences and as always, we will have our flagship medical device, the Adtec SteriPlas, on demonstration ready for you to test and to see all the benefits linked to our cold plasma strengths for wounds, surgical site infections and medical dermatology.

 

 

 

 


Promising, consistent and reliable results achieved with the Adtec SteriPlas

 

Whilst Left ventricular assist devices (LVADs) have become essential mechanical pumps for patients who have had end stage heart failures, they are also prone to infections especially with the presence of biofilm that complicates treatment options. Cardiologists often rely on conventional antibiotic therapy but with rising antimicrobial resistance rates, they sometimes offer little to no help in achieving stabilisation.

The strong properties of the Adtec SteriPlas cold plasma has been proven to offer complete stabilisation of the LVAD system by destroying all forms of multi-resistant bacteria present, even if they are protected within biofilm. This is due to the unique cold plasma properties that can travel through the gaps around and down the driveline to reach the site of biofilm. This area would normally have been difficult to treat with conventional therapies such as antimicrobial dressings as they are hard to reach, but the Adtec SteriPlas has shown to travel to these sites with ease due to its remarkable antibacterial gaseous properties.

 

To learn more about our strong collection of clinical evidence, please contact us at info@adtecplasma.com to learn more


E-poster at the EADV 2021 Conference

 

We look forward to supporting Fiona Koch’s e-poster that will be live during the EADV 2021 Spring Symposium tomorrow. Tune in to their website to get full access to her poster, “Efficacy of cold atmospheric plasma versus diclophenac 3% gel in patients with actinic keratoses: a prospective, randomized and rater-blinded study (ACTICAP)”.

 

To learn more about the Adtec SteriPlas’ strong clinical efficacy for the treatment of actinic keratoses, contact us at info@adtecplasma.com


The Adtec SteriPlas featured in another Actinic Keratoses publication

We would like to congratulate Dr Mariachiara Arisi and her team at The Department of Dermatology, Brescia Hospital in Italy for their latest publication: “Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation”.

 

This publication features the Adtec SteriPlas and further demonstrates its efficacy for treating complicated Actinic Keratoses (AK) lesions. All patient enrolled into this study had previously shown resistance or intolerance to conventional field-directed therapies. The results of the study show how all patients who received treatment with the Adtec SteriPlas had significantly reduced AK lesions with the benefit of no side effects observed, quite the opposite for conventional therapies that often bear undesirable side effects. The Adtec SteriPlas continues to be a favoured treatment alternative for actinic keratoses by continuing to be faster-acting, safer and reliable.

 

You can read the full publication here: https://link.springer.com/article/10.1007%2Fs13555-021-00514-y