The different methodsof plasma generation

The unique 'plasma blend' produced by a device is influenced by both the method of plasma generation—whether through radio frequency, microwave, or direct current—and the choice of carrier gas, such as air, argon, helium, or nitrogen. This means that each plasma device is unique.

The specificity of each plasma type means they cater to distinct treatments. It's crucial to understand that equivalence among cold plasma devices is not straightforward, as the plasma characteristics at the treatment site vary. Manufacturers have a professional responsibility to provide clinical evidence unique to their technology, and under EU MDR, product claims should be based solely on this evidence.

Adtec's PremiumCold Plasma

Our Premium Cold Plasma has been specifically designed to be a denser plasma, making it the most effective plasma in treating wounds.1

All cold plasma will kill bacteria in planktonic free-living state but not all cold plasmas have the required energy and density to kill bacteria in chronic infections.

Adtec's patented design harnesses the power of 2.45GHz microwave plasma (high-density) with the reliability of argon as the carrier gas, ensuring safety, control, and consistency.

Why you needdenser plasma

The objective is to deliver a safe dense cold plasma over a wide area with a short treatment time to treat the patient. A denser plasma can penetrate deeper into the wound and heal wounds and infections that other plasmas cannot reach.

We use microwave energy to ignite our argon plasma, which allows us to produce high-density plasmas at reduced voltages. Compared to direct current or DBD, this higher frequency achieves plasma generation with less input power. The lower electric fields associated with high-frequency plasma enhance safety by minimising the risks of electrical leakage and shock.

Greater efficacy:The only plasma to break the biofilm

High-density plasma can permeate biofilm, effectively eliminating the bacteria housed within it. The reactive species, heat, UV and ions which have higher energy than argon molecules bombard the bacteria cell wall creating micropores and rupturing the cell wall.
Adtec’s SteriPlas® is the only plasma dense enough to penetrate the biofilm.
A persistent, non-healing wound may indicate the presence of a biofilm, which often resists conventional wound care methods. In fact, bacteria protected within biofilm are up to 1,000x more resistant to antibiotics which severely complicates treatment options.2 To mitigate the threat of invasive infection, it's essential to reduce the components of biofilm, including its intracellular and planktonic niches.

While all cold plasmas can target free-living bacteria, not all possess the energy and density for chronic infections as they are unable to penetrate the biofilm. A 5-minute treatment with dense plasma eradicates 100% of biofilm bacteria.3

Given its physical mode of action, bacteria are unlikely to develop resistance to cold plasma making it effective against both biofilm and antibiotic-resistant bacteria, MRSA included.4 Read more

Denser plasma requires a bigger device

Years of innovation has led to a larger device as increased power is necessary to create the desired density of plasma. This not only streamlines the treatment process but also facilitates treating larger infection areas more swiftly.

For application, the treatment with SteriPlas® head is positioned over the wound, typically lasting between 2 to 5 minutes. Even a sizable wound, measuring 48cm2, can be addressed in just 8 minutes. Unlike smaller delivery systems, the larger head ensures a more effective and uniform treatment, significantly reducing the risk of missing any sections of the wound which can lead to compromised efficacy.

The procedure is non-invasive since plasma does not penetrate skin cells and does not leave any residue or have any unwanted side effects. Furthermore, the treatment is localised, targeting only the bacteria at the infection site leaving other healthy bacteria colonies in the body unaffected. Read more

Leading the wayin cold plasma

Our commitment to innovation and heritage in Semiconductor manufacturing equipment, has culminated in the development of the most potent cold plasma treatment, a claim substantiated by clinical studies. The efficacy of our treatment is a direct result of the meticulously crafted blend of plasma we’ve designed.

“Treating patients with Adtec‘s cold plasma has been one of the most exciting innovations in infection treatments that I have ever had the privilege of being involved in.”

Dr Michael Pierides

Consultant Endocrinologist and Diabetologist
Kettering General Hospital

References
1. Biomed, Perfectus. ‘Anti-Biofilm Activity Demonstrated Following Treatment with a Novel Plasma Device | Perfectus Biomed’, 9 November 2015. https://perfectusbiomed.com/anti-biofilm-activity-demonstrated-following-treatment-with-a-novel-plasma-device-booth-r-cutting-k-f-and-westgate-s-j-2015/.
2. Guo, Julan, Yuxing Huang, Bojun Xu, and Jiao Yang. ‘Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs’. Computational and Mathematica Methods in Medicine 2022 (2022): 5798857. https://doi.org/10.1155/2022/5798857.
3. Potera, Carol. ‘ANTIBIOTIC RESISTANCE: Biofilm Dispersing Agent Rejuvenates Older Antibiotics’. Environmental Health Perspectives 118, no. 7 (July 2010): A288.
4. Zimmermann, J. L., T. Shimizu, H.-U. Schmidt, Y.-F. Li, G. E. Morfill, and G. Isbary. ‘Test for Bacterial Resistance Build-up against Plasma Treatment’. New Journal of Physics 14, no. 7 (July 2012): 073037. https://doi.org/10.1088/1367-2630/14/7/073037.